Kazuharu Arakawa

Comparative genomics reveals signatures of distinct metabolic strategies and gene loss associated with Hydra immortality

The paper compares the genomes of two Hydra species, finding that the immortal species lacks anti-aging genes and has a distinct metabolic signature.

Microbe-dependent inter-organ communication regulates germline stem cell proliferation in Drosophila

This study shows that gut microbes influence germline stem cell proliferation in Drosophila by modulating metabolism, circadian genes, and hormonal signaling across tissues.

Image-scanning light-sheet microscopy for high-speed volumetric imaging of complex biological dynamics

The paper introduces image-scanning light-sheet microscopy to enable high-speed volumetric imaging of complex biological dynamics with improved speed while maintaining resolution and efficiency.

Pigment-dispersing factor neuropeptides act as multifunctional hormones and modulators in tardigrades

This study identifies three PDFs in tardigrades and shows they function as multifunctional hormones and neuromodulators involved in various physiological processes.

Post-embryonic tail development through molting of the freshwater shrimp Neocaridina denticulata

This study investigates tail development in Neocaridina denticulata through histology, live imaging, and genome sequencing, revealing cuticle branching, anisotropic furrows, and cellular dynamics during molting.

Sexual dimorphism in the tardigrade Paramacrobiotus metropolitanus transcriptome

This study identifies sex-biased genes and DMRT paralogs in the tardigrade Paramacrobiotus metropolitanus, revealing insights into sexual dimorphism and stress tolerance mechanisms.

Transcriptome analysis of the tardigrade Hypsibius exemplaris exposed to the DNA-damaging agent bleomycin

This study analyzes the transcriptome of Hypsibius exemplaris exposed to bleomycin, identifying tardigrade-specific gene families and tryptophan metabolism pathway enrichment linked to stress tolerance.

Composition of minor ampullate silk makes its properties different from those of major ampullate silk

The paper investigates the composition and properties of minor ampullate silk (MI-silk) compared to major ampullate silk (MA-silk) and identifies MaSp2 as the factor affecting water resistance.

in vivo expression vector derived from anhydrobiotic tardigrade genome enables live imaging in Eutardigrada

The paper develops a genetic tool for tardigrades to study anhydrobiosis by enabling live imaging of protein dynamics.

Darwin's bark spider shares a spidroin repertoire with Caerostris extrusa but achieves extraordinary silk toughness through gene expression

The paper investigates spidroin sequences and gene expression in Darwin's bark spider and its relative, finding that while spidroin genes are conserved, higher expression in Darwin's bark spider contributes to its tougher silk.

Multicomponent nature underlies the extraordinary mechanical properties of spider dragline silk

The paper identifies the multicomponent nature of spider dragline silk and shows that its mechanical properties arise from the combination of specific spidroin and SpiCE proteins.

A novel Mn-dependent peroxidase contributes to tardigrade anhydrobiosis

This study identifies a novel Mn-dependent peroxidase involved in tardigrade anhydrobiosis through transcriptomic and crystallographic analyses.

Multiomics study of a heterotardigrade, Echinisicus testudo, suggests convergent evolution of anhydrobiosis-related proteins in Tardigrada

This study identifies novel anhydrobiosis-related proteins in the heterotardigrade Echiniscus testudo, showing structural changes similar to eutardigrades but lacking sequence conservation, suggesting convergent evolution.

Comparative genomics of the tardigrades Hypsibius dujardini and Ramazzottius varieornatus

The paper compares the genomes of two tardigrade species to investigate their evolutionary relationships and mechanisms of extreme survival.

Genome sequencing of a single tardigrade Hypsibius dujardini individual

The paper describes a method to sequence the genome of a single tardigrade using an ultra-low input library protocol to reduce contamination.