Wenting Bian

Functional Characterization of Lipid Regulatory Effects of Three Genes Using Knockout Mouse Models

The paper identifies three causal lipid genes using Mendelian randomization and confirms their effects through mouse knockout studies and RNA-seq analysis.

Binary Interactome Models of Inner- Versus Outer-Complexome Organization

The paper constructs a high-quality yeast binary interactome map and compares inner- and outer-complexome organization, finding the outer-complexome contains more interactions and exhibits higher functional heterogeneity.

Maximizing binary interactome mapping with a minimal number of assays

The paper introduces an assayome concept to optimize binary interactome mapping by combining multiple assay versions, achieving high true positive detection with minimal assays.

A reference map of the human protein interactome

The paper presents HuRI, a comprehensive human protein-protein interaction map, and demonstrates its utility in understanding cellular function and disease mechanisms.

Network-based prediction of protein interactions

The paper challenges the Triadic Closure Principle in protein interaction prediction and introduces the L3 principle, which outperforms existing methods and identifies novel interactions.