Thomas Edward Hall

A modular encapsulation system for precision delivery of proteins, nucleic acids and small molecules

This paper introduces caveospheres, a modular nanovesicle system for targeted delivery of various cargo, demonstrating efficacy in both in vitro and in vivo applications.

A structural transition ensures robust formation of skeletal muscle

This study investigates how the zebrafish myotome forms a robust 3D structure through a structural transition involving cell rearrangement and mechanical plasticity.

A Standardized Protocol to Investigate Trans-Endothelial Trafficking in Zebrafish: Nano-bio Interactions of PEG-based Nanoparticles in Live Vasculature

This paper develops a standardized protocol to assess nanoparticle trans-endothelial trafficking in zebrafish, identifying transport mechanisms for PEG-based nanoparticles.

Unsaturated lipids as key control points for caveola formation and disassembly

This study identifies specific unsaturated lipids as critical for caveola formation and their disassembly under oxidative stress.

Cavin1 binding nanobodies reveal structural flexibility and regulated interactions of the N-terminal coiled-coil domain

The paper develops nanobodies that bind Cavin1's HR1 domain, revealing structural flexibility and regulated interactions important for caveolae assembly.

Cre-Lox miRNA-delivery technology optimized for inducible microRNA and gene-silencing studies in zebrafish.

The paper develops an inducible miRNA-delivery system in zebrafish to enable spatiotemporal gene silencing and traceable knockdowns, improving upon existing methods for studying microRNA biology and genetic disorders.

In Vivo Validation of Bimolecular Fluorescence Complementation (BiFC) to Investigate Aggregate Formation in Amyotrophic Lateral Sclerosis (ALS)

The paper validates and optimizes Bimolecular Fluorescence Complementation (BiFC) in zebrafish to study ALS-linked protein aggregate formation in vivo.

Pipeline for generating stable large genomic deletions in zebrafish, from small domains to whole gene excisions

The paper describes a method to generate stable large genomic deletions in zebrafish using CRISPR/Cas9, demonstrating its effectiveness for various deletion sizes and gene families.