Ka Chun Cheung

iPSC-derived hepatocytes accurately recapitulate population diversity in alpha-1-antitrypsin deficiency and offer a novel in vitro model for large-scale drug efficacy screening studies.

This study generates iPSC-derived hepatocytes from A1ATD donors and shows they recapitulate disease features and respond to drug treatments, offering a model for drug screening.

Deepurify: a multi-modal deep language model to remove contamination from metagenome-assembled genomes

Deepurify uses a multi-modal deep language model with contrastive learning to improve MAG decontamination by leveraging genomic sequences and taxonomic lineages.