Amy Adair

Nanobodies against Plasmodium vivax AMA1 block parasite invasion

The paper identifies nanobodies against PvAMA1 that inhibit Plasmodium vivax and falciparum invasion by binding novel epitopes distinct from known antibodies.

Nanobodies against Plasmodium adhesins that block receptor engagement and malaria parasite invasion

This study identifies nanobodies that target Plasmodium adhesins, blocking receptor engagement and inhibiting parasite invasion of red blood cells.

alpseq: an open-source workflow to turbocharge nanobody discovery with high-throughput sequencing

alpseq is an open-source pipeline for processing NGS data from nanobody libraries, enabling efficient analysis and identification of enriched sequences.

Pfs48/45 nanobodies block Plasmodium falciparum transmission

This paper identifies nanobodies against Pfs48/45 that reduce malaria parasite transmission by inhibiting fertilization in Anopheles mosquitoes.

Crystal structure and nanobodies against domain 3 of the malaria parasite fusogen Plasmodium falciparum HAP2

The paper identifies nanobodies targeting domain 3 of PfHAP2 and determines its crystal structure, providing structural insights for transmission-blocking interventions against malaria.

Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex

The paper determines the cryo-EM structure of the Plasmodium falciparum Pfs230-Pfs48/45 fertilization complex and identifies domains critical for function and vaccine design.