Jill Chmielewski

Nanobodies against Plasmodium vivax AMA1 block parasite invasion

The paper identifies nanobodies against PvAMA1 that inhibit Plasmodium vivax and falciparum invasion by binding novel epitopes distinct from known antibodies.

An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodies

This study shows that PfMSP2 modulates the susceptibility of merozoites to inhibitory antibodies targeting other invasion proteins, altering malaria vaccine strategies.

Nanobodies against Plasmodium adhesins that block receptor engagement and malaria parasite invasion

This study identifies nanobodies that target Plasmodium adhesins, blocking receptor engagement and inhibiting parasite invasion of red blood cells.

Pfs48/45 nanobodies block Plasmodium falciparum transmission

This paper identifies nanobodies against Pfs48/45 that reduce malaria parasite transmission by inhibiting fertilization in Anopheles mosquitoes.

Crystal structure and nanobodies against domain 3 of the malaria parasite fusogen Plasmodium falciparum HAP2

The paper identifies nanobodies targeting domain 3 of PfHAP2 and determines its crystal structure, providing structural insights for transmission-blocking interventions against malaria.

Differential importance of MSP4 and MSP5 for infection of red blood cells between human infecting malaria parasites

This study compares the roles of MSP4 and MSP5 in red blood cell invasion across malaria species, showing differential importance and highlighting MSP5 as a potential vaccine target for P. knowlesi and P. vivax.

Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex

The paper determines the cryo-EM structure of the Plasmodium falciparum Pfs230-Pfs48/45 fertilization complex and identifies domains critical for function and vaccine design.