Author

Rajgopal Govindarajan

The Ohio State UniversityORCID 0000-0002-2958-5773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Amy WebbiD· 3 shared Claire BryantiD· 3 shared Shipra AgrawaliD· 3 shared Alessia FornoniiD· 1 shared Alexander S. BanksiD· 1 shared Amanda P. WalleriD· 1 shared Angélica Amorim AmatoiD· 1 shared Brian BecknelliD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersMolecular Biology

Amy WebbORCID

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3 papers

Recent·Most cited

RNA Alternative Splicing and Polyadenylation and Regulation of the Glomerular Filtration Barrier

Monoj K Das, Amy Webb, Mahika Yarram, Christian Reilly, Lalith Punepalle Raveendrareddy, Claire Bryant, Rajgopal Govindarajan, Claire L. Moore, Shipra Agrawal

This study identifies altered alternative splicing and polyadenylation in glomerular genes during kidney disease models and demonstrates potential therapeutic modulation using antisense oligonucleotides.

Journal of the American Society of Nephrology · May 21, 2025Peer-reviewedMolecular Biology

Alternatively Spliced Landscape of PPARγ mRNA in Podocytes is Distinct from Adipose Tissue

Claire Bryant, Amy Webb, Alexander S. Banks, Dawn S. Chandler, Rajgopal Govindarajan, Shipra Agrawal

The paper identifies distinct PPARγ mRNA variants in podocytes compared to adipose tissue, highlighting differences in splicing patterns and regulatory mechanisms.

Cells · Nov 1, 2022Peer-reviewedMolecular Biology

Selective Modulator of Nuclear Receptor PPARy with Reduced Adipogenic Potential Ameliorates Experimental Nephrotic Syndrome

Claire Bryant, Galen C. Rask, Amanda P. Waller, Amy Webb, Marina Galdino da Rocha Pitta, Angélica Amorim Amato, Rachel E. Cianciolo, Rajgopal Govindarajan, Brian Becknell, Bryce A. Kerlin, Francisco de Assis Rocha Neves, Alessia Fornoni, Shipra Agrawal

This study compares the effects of GQ-16, a PPARγ partial agonist, and pioglitazone, a PPARγ full agonist, in treating nephrotic syndrome in rats, finding that GQ-16 reduces proteinuria and co-morbidities with fewer adipogenic side effects.

iScience · Feb 28, 2022Peer-reviewedMolecular Biology