Computational prediction of MHC anchor locations guide neoantigen identification and prioritization
Huiming Xia, Joshua F. McMichael, Michelle Becker‐Hapak, Onyinyechi C. Onyeador, Rico Buchli, Ethan D. McClain, Patrick Pence, Suangson Supabphol, Megan M. Richters, Anamika Basu, Cody A. Ramirez, Cristina Puig-Saus, Kelsy C. Cotto, Sharon L. Freshour, Jasreet Hundal, , Malachi Griffith
The paper predicts MHC anchor positions for 328 HLA alleles and shows that incorporating these improves neoantigen identification by correcting misclassified candidates in tumor samples.
Science Immunology · Apr 7, 2023Peer-reviewedBioinformatics