Author

Alyna Katti

Revolution Medicines (United States)ORCID 0000-0002-9662-965XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Lukas E. DowiD· 2 shared Miguel ForondaiD· 2 shared Sukanya GoswamiiD· 2 shared Adrian Vega· 1 shared Aidan C.A. TomlinsoniD· 1 shared Amber Simon· 1 shared Anabel Y. Schweitzer· 1 shared Benjamin I. LeachiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Lukas E. DowORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Genetic mechanisms of resistance to targeted KRAS inhibition

Bianca Jay Diaz, M.S. Kops, Sara Bernardo, Henri Schmidt, Elizabeth Grankowsky, Adrian Vega, Chen Zhang, Matthew Joseph Bott, Maria Skamagki, Aidan C.A. Tomlinson, Nicole A. Vita, Alyna Katti, Mark P. Labrecque, Ida Aronchik, Mallika Singh, Lukas E. Dow

This study identifies genetic mechanisms of resistance to KRAS inhibitors by using CRISPR screens to find resistance mutations and signaling rewiring in NSCLC.

bioRxiv · Aug 4, 2025 · PreprintCancer Biology

A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression

Jill Zimmerman, Brandon F Malone, Efrat Finkin-Groner, Shan Sun, Rui Liang, Miguel Foronda, Emma M. Schatoff, Elizabeth Granowsky, Sukanya Goswami, Alyna Katti, Benjamin I. Leach, Heather L. Alcorn, Tuomas Tammela, Yoshiyuki Fukase, Tanweer A. Khan, , Lukas E. Dow

The paper identifies a TNKS2-selective inhibitor that enables tumor-selective WNT suppression by exploiting 8p loss in cancer cells.

bioRxiv · Mar 4, 2025 · PreprintCancer Biology

An optimized toolkit for precision base editing

Maria Paz Zafra, Emma M Schatoff, Alyna Katti, Miguel Foronda, Marco Breinig, Anabel Y. Schweitzer, Amber Simon, Teng Han, Sukanya Goswami, Emma Montgomery, Jordana Thibado, Francisco J. Sánchez-Rivera, Junwei Shi, Christopher R Vakoc, Scott W Lowe, , Lukas E Dow

This paper develops a toolkit for precision base editing, improving the efficiency and ease of creating single nucleotide variants across various model systems.

bioRxiv · Apr 17, 2018 · PreprintBioengineering