Minimal essential requirements for neural tube self-organisation
Hannah T. Stuart, Elena Costantini, Jingkui Wang, Teresa Krammer, M. Joaquina Delàs, Manuela Melchionda, Jake Cornwall-Scoones, Gerald Schmauss, Thomas Lendl, Keisuke Ishihara, David A. J. Rand, Meritxell Sáez, Elly Margaret Tanaka, James Briscoe
The paper shows that RA induces a transient co-expression state of PAX6 and FOXA2 in neural tube organoids, leading to two opposing cell fates that determine cell-type proportions through feedback signaling.
bioRxiv · Jun 8, 2026 · PreprintDevelopmental Biology