Jingkui Wang

Minimal essential requirements for neural tube self-organisation

The paper shows that RA induces a transient co-expression state of PAX6 and FOXA2 in neural tube organoids, leading to two opposing cell fates that determine cell-type proportions through feedback signaling.

Functional rescue of critical-size bone defect using molecular network analysis of axolotl limb regeneration.

The paper identifies molecular differences between regenerating blastema and non-regenerating CSD in axolotl limbs and uses Wnt3a expression to induce cartilage bridging in CSD.

AXL governs axolotl cardiac regeneration and directs mammalian cardiomyocyte dedifferentiation

This study identifies AXL as a key regulator of cardiac regeneration in axolotls and shows its role in inducing cardiomyocyte dedifferentiation in mammals without cell cycle re-entry.

Circuit to target approach defines an autocrine myofibroblast loop that drives cardiac fibrosis

The paper models a macrophage-myofibroblast circuit to predict fibrosis types and shows targeting the myofibroblast autocrine loop reduces fibrosis after myocardial infarction.

Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types

The paper introduces mime-seq 2.0, a method to sequence microRNAs from specific mouse cell types using a chimeric RNA methyltransferase tethered to Argonaute.

Buckling instability underlies vertebral segmentation during axolotl tail regeneration

The paper shows that vertebral segmentation during axolotl tail regeneration occurs via a buckling instability mechanism, distinct from the somite-based process in embryonic development.

Loss of Cohesin regulator PDS5A reveals repressive role of Polycomb loops

The paper identifies PDS5A as a cohesin regulator linking Polycomb silencing and 3D genome organization, showing that its loss disrupts cohesin activity and Polycomb loops without affecting repressive chromatin marks.

Neural tube organoids self-organise floorplate through BMP-mediated cluster competition

The paper shows how floorplate organiser forms autonomously in neural tube organoids through BMP-mediated cluster competition and FOXA2 dynamics.

Chromatin states at homeoprotein loci distinguish axolotl limb segments prior to regeneration

The paper identifies segment-specific chromatin states at homeoprotein loci in axolotl limb segments, showing how positional information is encoded for regeneration.

ZFP462 targets heterochromatin to transposon-derived enhancers restricting transcription factor binding and expression of lineage-specifying genes

This study identifies ZFP462's role in restricting endodermal gene expression by targeting transposon-derived enhancers and modulating histone methylation in mouse embryonic stem cells.

Two microRNAs are sufficient for embryogenesis in C. elegans

The paper shows that two microRNAs from the miR-35 and miR-51 families are sufficient for normal embryogenesis in C. elegans, rescuing developmental defects caused by Microprocessor depletion.