Author

Simon A. S. Pope

National Hospital for Neurology and NeurosurgeryORCID 0000-0002-2991-3722Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Simon HealesiD· 2 shared Abi Li· 1 shared Alejandro HorgaiD· 1 shared Alex MontoyaiD· 1 shared Amelie Pandraud· 1 shared Andreea ManoleiD· 1 shared Andrew SingletoniD· 1 shared Andrey Y. AbramoviD· 1 shared

Activity by Year

2017-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Simon HealesORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multi-Omic Analysis Reveals Lipid Dysregulation Associated with Mitochondrial Dysfunction in Parkinson's Disease Brain

Jenny Hällqvist, Christina E. Toomey, Rui Climaco Pinto, Tomas Baldwin, Ivan Doykov, Anna I. Wernick, Mesfer Mohammad Al Shahrani, James R. Evans, Joanne Lachica, Simon A. S. Pope, Simon Heales, Simon D. Eaton, Kevin A. Mills, Sonia Gandhi, Wendy Heywood

This study identifies lipid dysregulation linked to mitochondrial dysfunction in Parkinson's Disease brain regions through multi-omics analysis of lipids, proteomics, and mitochondrial activity.

Nature Communications · Nov 25, 2025Peer-reviewedNeuroscience

Mitochondrial dysfunction underlies monocyte immune deficiency in patients with severe alcohol-related hepatitis

Paul K. Middleton, Ricardo J. Aramayo, Alex Montoya, Pavel V. Shliaha, Simon A. S. Pope, Louise Fets, Nikhil Vergis, Mark R. Thursz, Helena M. Cochemé

This study shows that mitochondrial dysfunction in monocytes of severe alcohol-related hepatitis patients contributes to immune deficiency.

bioRxiv · Jan 28, 2025 · PreprintImmunology

Mitochondrial impairment and rescue in riboflavin responsive neuropathy

Andreea Manole, Zane Jaunmuktane, Iain Parry Hargreaves, Marthe H. R. Ludtmann, Vincenzo Salpietro, Oscar Daniel Bello, Simon A. S. Pope, Amelie Pandraud, Alejandro Horga, R. Scalco, Abi Li, Balasubramaniem Ashokkumar, Charles Marques Lourenço, Simon Heales, Rita Horváth, , Henry Houlden

This study identifies RFVT gene mutations in BVVLS, shows mitochondrial dysfunction, and demonstrates therapeutic potential with riboflavin esters.

Brain · Aug 23, 2017Peer-reviewedNeuroscience