Pavel V. Shliaha

This study deletes nine NAPs from E. coli to create a strain lacking native chromatin, revealing gene expression homogenization and demonstrating that bacterial life can proceed without chromatin proteins.

This study identifies and characterizes cinquedea, a bactericidal phospholipase from the archaeon Haloferax larsenii that kills halophilic bacteria by damaging their cell membranes.

The paper uses multimodal imaging to show that lysosomes act as a reservoir for PARP inhibitors, leading to heterogeneous drug distribution and response in ovarian cancer.

This study identifies a new role for Wee1 in promoting S-phase entry by inhibiting APC/CCdh1, revealing a mechanism that impacts the efficacy and toxicity of Wee1 inhibitors in cancer treatment.

This study identifies antagonistic interactions between archaea and bacteria by analyzing genome sequences and demonstrating the antibacterial activity of archaeal peptidoglycan hydrolases.

This study shows that mitochondrial dysfunction in monocytes of severe alcohol-related hepatitis patients contributes to immune deficiency.

This study shows that enhancing autophagy through redox regulation extends lifespan in Drosophila by highlighting the role of a specific cysteine residue in Atg4a.

The paper shows PBK/TOPK phosphorylates Ikaros, Aiolos, and CTCF to displace them from mitotic chromosomes, altering chromatin accessibility at specific zinc finger protein sites.

This study identifies conserved helical motifs in Ikaros that mediate NuRD interaction and transcriptional repression in pre-B cells and B-ALL.

This study shows that histones are essential and form chromatin in bacteria, with a unique DNA binding mode compared to archaea and eukaryotes.