Author

Mark R. Thursz

Imperial College LondonORCID 0000-0002-8218-192XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Abraham A. PalmeriD· 1 shared Alex MontoyaiD· 1 shared Alice R. Rothwell· 1 shared Amandine EverardiD· 1 shared Amy C. JusticeiD· 1 shared Ana Luísa NevesiD· 1 shared Anders Dupont BørglumiD· 1 shared Andrew McQuilliniD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperGenetics

Abraham A. PalmerORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control

Julien Chilloux, François Brial, Amandine Everard, David R. Smyth, Petros Andrikopoulos, Liyong Zhang, Hubert Plovier, Antonis Myridakis, Lesley Hoyles, José María Moreno‐Navarrete, Jèssica Latorre, Viviana Casagrande, Rossella Menghini, Blerina Ahmetaj‐Shala, Christine Blancher, , Marc‐Emmanuel Dumas

This study identifies trimethylamine (TMA) as a microbial compound that inhibits IRAK4, reducing inflammation and improving metabolic outcomes in high-fat diet conditions.

Nature Metabolism · Dec 8, 2025Peer-reviewedPhysiology

Mitochondrial dysfunction underlies monocyte immune deficiency in patients with severe alcohol-related hepatitis

Paul K. Middleton, Ricardo J. Aramayo, Alex Montoya, Pavel V. Shliaha, Simon A. S. Pope, Louise Fets, Nikhil Vergis, Mark R. Thursz, Helena M. Cochemé

This study shows that mitochondrial dysfunction in monocytes of severe alcohol-related hepatitis patients contributes to immune deficiency.

bioRxiv · Jan 28, 2025 · PreprintImmunology

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

Hang Zhou, Julia Sealock, Sandra Sanchez‐Roige, Toni‐Kim Clarke, Daniel F. Levey, Zhongshan Cheng, Boyang Li, Renato A Polimanti, Rachel L. Kember, Rachel Vickers‐Smith, Johan H. Thygesen, Marsha Yvonne Morgan, Stephen R. Atkinson, Mark R. Thursz, Mette Nyegaard, , Joel E. Gelernter

This study identifies 29 risk variants for problematic alcohol use through a large meta-analysis and explores its genetic relationships with other traits.

Nature Neuroscience · May 25, 2020Peer-reviewedGenetics