Katrina I Ellestad

This study identifies microbiome-derived hydroxyphenyl propanoates (HPPs) that enhance antitumour immunity by boosting gasdermin D activity in myeloid cells, improving immune checkpoint therapy outcomes in mice and correlating with better responses in human melanoma patients.

This study identifies two epigenetically-defined spatial niches in glioblastoma that influence cell state plasticity through local and long-range molecular signals.

Copy-scAT deconvolutes single-cell chromatin accessibility to infer genetic subclones in cancer, revealing how genetics influence chromatin profiles and subclonal phenotypes.