This paper introduces PRIME-VLP, a delivery strategy that enhances prime editing efficiency for genome engineering and high-throughput screening using eVLPs.

Cell Genomics · Jul 14, 2026Peer-reviewedGenomics

Microbiome-derived hydroxyphenyl propanoates enhance antitumour immunity by potentiating gasdermin D activity in tumour-associated myeloid cells

Saif Sikdar, D Kim, Tie Wang, Sacha Benaoudia, Jahanara Rajwani, Kristofor K. Ellestad, Pauline Douglas, Růžena Filandrová, Theodore B. Verhey, Katrina I Ellestad, Marija Drikic, D.R. Derksen, Ian A. Lewis, Marco Gallo, A. Sorana Morrissy, , Douglas J. Mahoney

This study identifies microbiome-derived hydroxyphenyl propanoates (HPPs) that enhance antitumour immunity by boosting gasdermin D activity in myeloid cells, improving immune checkpoint therapy outcomes in mice and correlating with better responses in human melanoma patients.

bioRxiv · Apr 27, 2026 · PreprintCancer Biology

Genetic variants disrupting activity-dependent CELF2 shuttling cause neuronal hyperexcitability, learning deficits, and seizures.

Michelle Hua, Mohamad‐Reza Aghanoori, Melissa J MacPherson, Yi Ren, Yifan Yang, Yan Yan Or, Laura Williams, Christopher J. Gafuik, Chloé Quēlin, Boris Keren, Sarah Schuhmann, Georgia Vasileiou, Alexia Bourgois, Antonio Vitobello, Christophe Philippe, , Guang Yang

The paper identifies CELF2 variants causing cytoplasmic mislocalization linked to neuronal hyperexcitability, learning deficits, and seizures.

medRxiv · Jun 20, 2025 · PreprintGenetic & Genomic Medicine