Ilya R. Bederman

Nonviral, ultrasound-triggered gene delivery platform via gas-core cationic nanobubbles

This paper develops a nonviral, ultrasound-triggered gene delivery platform using cationic nanobubbles that achieve efficient, site-specific gene expression in vitro and in vivo.

Critical Process Steps for Mechanical Agitation Driven Coated Nanobubble Self Assembly

This paper identifies critical process parameters for producing stable, uniform coated nanobubbles via mechanical agitation.

Clonal Parabacteroides from Gut Microfistulous Tracts as Transmissible Cytotoxic Succinate-Commensal Model of Crohn's Disease Complications

The paper identifies clonal Parabacteroides distasonis isolates from CD-associated gut fistulas that exhibit pathogenic traits in mouse models and show potential for transmissibility and adaptation to CD-like ileitis.

Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

This study shows chronic ER stress induces β-cell plasticity, but excessive stress leads to identity loss and is linked to T1D progression.

Enhancers of human and rodent oligodendrocyte formation predominantly induce cholesterol precursor accumulation

This study identifies that many molecules promoting oligodendrocyte formation inhibit cholesterol pathway enzymes, with a focus on EBP, and proposes a model for their mechanism.

Non-Canonical Targets of HIF1a Drive Cell-Type-Specific Dysfunction

This study identifies non-canonical HIF1a targets that impair oligodendrocyte progenitor cell function and drive disease in chronic hypoxia.