Daehun Park

DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

The paper shows that DDHD2 is essential for neurons to use fatty acids from lipid droplets as an energy source during activity when glucose is unavailable.

Phosphoglycerate kinase 1 is a central leverage point in Parkinson's disease driven neuronal metabolic deficits

The paper identifies PGK1 as a rate-limiting enzyme in axonal metabolism and shows its protective role against Parkinson's disease-related synaptic deficits.

Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles

The paper shows that synaptophysin and synaptogyrin family proteins co-express with synapsin to generate small vesicles and that their absence leads to larger synaptic vesicles.

Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates

The paper shows that ATG9A forms distinct vesicle phases from synaptic vesicle proteins within synapsin condensates in fibroblasts and nerve terminals.

Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9

This study identifies ATG-9 trafficking as a mechanism linking presynaptic autophagy to the synaptic vesicle cycle in C. elegans.

Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1

The paper shows that combining a Parkinson's disease mutation in synaptojanin 1 with Sac2 knockout in mice leads to severe neurological defects, suggesting Sac2 as a PD risk gene.