Laurie T. Krug

Mapping herpesvirus-driven impacts on the cellular milieu and transcriptional profile of Kaposi sarcoma in patient-derived mouse models

This study establishes patient-derived KS xenografts that maintain KSHV infection and recapitulate KS tumor gene signatures, enabling analysis of tumor microenvironment cell communications.

UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repair

The paper identifies the UNG-RPA interaction as determining whether uracil repair is high-fidelity or mutagenic in B cells.

Eph Receptor Tyrosine Kinases Are Functional Entry Receptors for Murine Gammaherpesvirus 68

This study identifies EphA4 and EphB3 as functional entry receptors for MHV68, demonstrating their role in viral infection and highlighting their potential as targets for neutralizing antibodies.

Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection

This study shows that a replication-dead murine gammaherpesvirus lacking pathogenesis genes can protect against wild-type virus infection by inducing neutralizing antibodies and CD8 T-cell responses.

A Recombinant Antibody For Tracking Murine Gammaherpesvirus 68 Uracil DNA Glycosylase Expression.

This paper describes the development and characterization of a recombinant antibody that specifically detects murine gammaherpesvirus 68's vUNG protein, with applications in immunostaining, microscopy, and flow cytometry.