Jonathan Evan Shoag

Paired plus-minus sequencing is an ultra-high throughput and accurate method for dual strand sequencing of DNA molecules

This paper introduces ppmSeq, a sequencing technology that improves accuracy and efficiency in detecting SNVs by sequencing both DNA strands, showing superior performance in clinical applications like ctDNA detection.

Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing

This paper develops a single-molecule long-read sequencing method to detect single-strand DNA mismatches and damage, revealing their relationship to double-strand mutations and providing insights into mutation mechanisms in cancer and aging.

Integrative genomic, transcriptomic, and epigenomic analyses of benign prostatic hyperplasia reveal new options for therapy

This study identifies molecular subgroups of BPH and suggests mTOR inhibitors as a potential therapy for specific subtypes.