The paper examines associations between epilepsy-related polygenic risk scores and brain morphology in children, finding PRS-related cortical thinning linked to structural patterns in TLE-HS patients.

Brain · Aug 8, 2025Peer-reviewedNeuroscience

A worldwide ENIGMA study on epilepsy-related gray and white matter compromise across the adult lifespan

Judy Chen, Alexander Ngo, Raúl Rodríguez‐Cruces, Jessica Royer, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon Sean Keller, Fernando Cendes, Clarissa Lin Yasuda, Marina K. M. Alvim, Leonardo Bonilha, Ezequiel L. Gleichgerrcht, Niels K. Focke, Barbara A. K. Kreilkamp, , Boris C. Bernhardt

This study examines age-related changes in grey and white matter in TLE patients across the adult lifespan, finding accelerated aging effects after age 55.

bioRxiv · Mar 2, 2024 · PreprintNeuroscience

Topographic divergence of atypical cortical asymmetry and regional atrophy patterns in temporal lobe epilepsy: a worldwide enigma study

Bo‐yong Park, Sara Larivière, Raúl Rodríguez‐Cruces, Jessica Royer, Shahin Tavakol, Yezhou Wang, Lorenzo Caciagli, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon Sean Keller, Fernando Cendes, Marina K. M. Alvim, Clarissa Lin Yasuda, Leonardo Bonilha, , Boris C. Bernhardt

This study identifies divergent patterns of atypical cortical asymmetry and regional atrophy in temporal lobe epilepsy using MRI data from a large multi-site cohort.

Brain · Nov 16, 2021Peer-reviewedNeuroscience

Structural network alterations in focal and generalized epilepsy follow axes of epilepsy risk gene expression: An ENIGMA study

Sara Larivière, Jessica Royer, Raúl Rodríguez‐Cruces, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon Sean Keller, Fernando Cendes, Clarissa Lin Yasuda, Leonardo Bonilha, Ezequiel L. Gleichgerrcht, Niels K. Focke, Martin Domín, Felix von Podewils, Sönke Langner, , Boris C. Bernhardt

This study links structural network changes in epilepsy syndromes to risk gene expression patterns using ENIGMA data.

bioRxiv · Oct 18, 2021 · PreprintNeuroscience

A systems-level analysis highlights microglial activation as a modifying factor in common forms of human epilepsy

André Altmann, Mina Ryten, Martina Di Nunzio, Teresa Ravizza, Daniele Tolomeo, Regina Hertfelder Reynolds, Alyma Somani, Marco Bacigaluppi, Valentina Iori, Edoardo Micotti, Rossella Di Sapia, Milica Cerovic, Eleonora Palma, Gabriele Ruffolo, Juan Antonio Botía, , Annamaria Vezzani

The paper identifies microglial activation as a factor contributing to cortical thinning in epilepsy by integrating neuroimaging and gene expression data.

Neuropathology and Applied Neurobiology · Aug 13, 2021Peer-reviewedNeuroscience

White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA Epilepsy study

Sean N. Hatton, Khoa H Huynh, Leonardo Bonilha, Eugenio Abela, Saud Alhusaini, André Altmann, Marina K. M. Alvim, Akshara R. Balachandra, Emanuele Bartolini, Benjamin Bender, Neda Bernasconi, Andrea Bernasconi, Boris C. Bernhardt, Núria Bargalló, Benoît Caldairou, , Carrie R. McDonald

This study identifies white matter microstructural differences across epilepsy syndromes using diffusion MRI data from a large multicenter cohort.

Brain · Jun 5, 2020Peer-reviewedNeuroscience

Network-based atrophy modelling in the common epilepsies: a worldwide ENIGMA study

Sara Larivière, Raúl Rodríguez‐Cruces, Jessica Royer, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon Sean Keller, Fernando Cendes, Clarissa Lin Yasuda, Leonardo Bonilha, Ezequiel L. Gleichgerrcht, Niels K. Focke, Martin Domín, Felix von Podewils, Sönke Langner, , Boris C. Bernhardt

This study identifies network associations with atrophy patterns in epilepsy using neuroimaging and connectome analysis across 1,021 patients and 1,564 controls.

bioRxiv · May 4, 2020 · PreprintNeuroscience