Author

Vanessa Donega

Amsterdam NeuroscienceORCID 0000-0002-3152-2675Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Elly M. HoliD· 2 shared Angélica María Sabogal-GuáquetaiD· 1 shared Anna van Regteren AltenaiD· 1 shared Anne C. RiosiD· 1 shared Anne‐Marie van DamiD· 1 shared Bernardo de A.P.C. MacieliD· 1 shared Chen Ji Rong Jiang· 1 shared Helga E. de VriesiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersNeuroscience

Elly M. HolORCID

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3 papers

Recent·Most cited

Microglia integration into midbrain organoids: Origin matters

Marloes Verkerke, Angélica María Sabogal-Guáqueta, Saloua Zekri, Anne‐Marie van Dam, Helga E. de Vries, Vanessa Donega

This study integrates postmortem PD microglia, iPSC-derived microglial progenitors, and iPSC-derived microglia into midbrain organoids, showing that postmortem microglia have higher infiltration capacity and better markers of maturity.

bioRxiv · Sep 24, 2026 · PreprintNeuroscience

Regional specificity of neuronal cell types, functional connectivity, and cell type-specific correlation to brain disorders in the human ventral tegmental area

Anna van Regteren Altena, Bernardo de A.P.C. Maciel, Rachel M. Brouwer, Chen Ji Rong Jiang, Sara Seoane, Ravian L. van Ineveld, Jonne M Eggink, Tiziana M. Hey, Anne C. Rios, R. Jeroen Pasterkamp, Vanessa Donega, Martijn P. van den Heuvel, Onur Başak, Elly M. Hol

This study creates a transcriptomic atlas of the human ventral tegmental area, identifies cell types and their functional connectivity, and links them to psychiatric disorders and BMI.

bioRxiv · Jun 9, 2026 · PreprintNeuroscience

Transcriptomic and functional analysis of Aβ1-42 oligomer-stimulated human monocyte-derived microglia-like cells

Tamar Smit, Paul R. Ormel, Jacqueline A. Sluijs, Lianne A. Hulshof, Jinte Middeldorp, Lot D. de Witte, Elly M. Hol, Vanessa Donega

This study examines the transcriptomic response of human monocyte-derived microglia-like cells to Aβ1-42 oligomers, finding increased metallothionein expression and no inflammatory or HAM/DAM profiles.

Brain Behavior and Immunity · Dec 9, 2021Peer-reviewedNeuroscience