Georgia K. Lagoudas

De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen

This study shows that de novo mutations in Burkholderia dolosa cause phenotypic switching, with O-antigen loss increasing immune cell uptake but reducing lung competitiveness, depending on infection duration and tissue localization.

A Bayesian model of acquisition and clearance of bacterial colonization incorporating within-host variation

The paper presents a Bayesian model to estimate bacterial acquisition and clearance rates by accounting for within-host genetic variation and sampling intervals, validated using simulations and applied to MRSA isolates.