Makoto Hayashi

EC-isHCR: a rapid method for in situ hybridization chain reaction in diverse animal samples

This paper demonstrates that EC-isHCR retains the features of conventional isHCR and introduces an automated probe design tool to enhance its applicability across diverse samples.

Somatic gene repression ensures physical segregation of germline and soma in Drosophila embryos

The paper shows that somatic gene silencing in Drosophila germline is essential for maintaining physical segregation from soma, preventing cell death and ensuring germline viability.

Nanos downregulates maternal mRNAs in germline during Drosophila early embryogenesis

The paper identifies maternal mRNAs downregulated by Nanos in Drosophila PGCs at the blastoderm stage, prior to zygotic genome activation.

Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in the adult Drosophila midgut

This study identifies Xrp1 as a key driver of damage-induced cellular plasticity in Drosophila enteroendocrine cells, enabling dedifferentiation and re-differentiation during regeneration.

snRNA-seq analysis of the moss Physcomitrium patens reveals a conserved cytokinin-ESR module promoting pluripotent stem cell identity

The paper uses snRNA-seq to analyze moss stem cells, identifying a cytokinin-ESR module that promotes pluripotent stem cell identity in the gametophore apical cell.