Matej Orešič

Measurement of a panel of 21 steroids in a quantitative assay in human plasma, adipose tissue, and fecal samples using ultra-high-performance liquid chromatography-tandem mass spectrometry

The paper develops a UHPLC-MS/MS assay to quantify 21 steroids in plasma, adipose tissue, and fecal samples with high sensitivity and accuracy.

Early life gut microbial and metabolic shifts reflected in stool consistency- a gut transit time proxy

This study links gut transit time, inferred from stool consistency, to microbial metabolites and microbiota in infants, showing associations with breastfeeding, bile acid metabolism, and short-chain fatty acids.

Feasibility of multimodal metabolic analysis for detecting early changes in acute neuroinflammation

This study uses multimodal metabolic analysis to detect early metabolic changes in acute neuroinflammation, showing reduced pyruvate metabolism and ongoing inflammation without structural MRI changes.

Temporal Associations Between Human Milk Metabolites and the Infant Gut Microbiome and metabolome

This study examines how human milk metabolites relate to the infant gut microbiome and metabolome over time, finding time-dependent associations and differential influences based on dietary changes.

Metabolic effects and biotransformation of perfluorohexyloctane (F6H8) in human hepatocytes

This study examines the metabolic effects and biotransformation of F6H8 in human hepatocytes, revealing concentration-dependent metabolic alterations and the formation of a PFAS-like biotransformation product.

Microbial lipid shifts in a multi-stage simulated gut

The paper uses a colon simulator to study microbial lipid shifts in the gut and validates findings using human samples.

Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples

The paper evaluates the type 1 error rate in bisulfite sequencing analysis of umbilical cord blood samples and finds that permutation-based significance analysis reduces it, with minimal differential methylation associated with clinical variables except sex.

Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis

The paper investigates the relationship between central CB1-receptor availability and peripheral endocannabinoids in first-episode psychosis patients and healthy controls, finding dysregulated cross-talk between these systems.

Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

This study examines how prenatal exposure to PFAS affects neonatal serum phospholipids and increases the risk of type 1 diabetes in offspring.

Metabolic Alterations in Human Peripheral Blood Mononuclear Cells Associate with Progression to Islet Autoimmunity and Type 1 Diabetes

The paper identifies metabolic patterns in PBMCs associated with progression to islet autoimmunity and T1D using longitudinal metabolomics and metabolic modeling.

Persistent alterations in plasma lipid profiles prior to introduction of gluten in the diet associate with progression to celiac disease

The paper identifies lipid profile changes in children before gluten introduction that associate with progression to celiac disease.