This study shows that early-life PFAS exposure causes sex-dependent metabolic changes in plasma and brain of mice, with females showing more extensive alterations.

bioRxiv · Oct 20, 2026 · PreprintPharmacology & Toxicology

Effects of incrementally increased plant-based protein intake on gut microbiota and inflammatory-metabolic biomarkers in healthy adults

Samira Bernardino Ramos do Prado, Annalena Kamm, Katharina Dannenberg, Isabel Keidel, Victor Castro‐Alves, Tuulia Hyötyläinen, Marleen A. H. Lentjes, Dirk Repsilber, Tatiana Milena Marques, Robert J. Brummer

This study examines how increasing pea protein intake affects gut microbiota and inflammatory biomarkers in healthy adults, finding changes in specific bacterial abundances and fecal markers.

Food & Function · Jan 1, 2026Peer-reviewedBiochemistry

Metabolic effects and biotransformation of perfluorohexyloctane (F6H8) in human hepatocytes

Andi Alijagić, Jade Chaker, João Marcos G. Barbosa, Daniel Duberg, Victor Castro‐Alves, Alex M. Dickens, Matej Orešič, Tuulia Hyötyläinen

This study examines the metabolic effects and biotransformation of F6H8 in human hepatocytes, revealing concentration-dependent metabolic alterations and the formation of a PFAS-like biotransformation product.

bioRxiv · Oct 24, 2025 · PreprintPharmacology & Toxicology

Microbial lipid shifts in a multi-stage simulated gut

Ifrat Tamanna, Katja Salonen, Helena Mannochio-Russo, Matilda Kråkström, Paulo Wender Portal Gomes, Vincent Charron‐Lamoureux, Ipsita Mohanty, Sofia D. Forssten, Arthur C. Ouwehand, Tuulia Hyötyläinen, Alex M. Dickens, Pieter C. Dorrestein, Matej Orešič, Santosh Lamichhane

The paper uses a colon simulator to study microbial lipid shifts in the gut and validates findings using human samples.

bioRxiv · Sep 25, 2025 · PreprintBiochemistry

Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis

Alex M. Dickens, Faith Borgan, Heikki Laurikainen, Santosh Lamichhane, Tiago Reis Marques, Tuukka Rönkkö, Mattia Veronese, Tuomas Lindeman, METSY Investigators, Tuulia Hyötyläinen, Oliver David Howes, Jarmo A. Hietala, Matej Orešič

The paper investigates the relationship between central CB1-receptor availability and peripheral endocannabinoids in first-episode psychosis patients and healthy controls, finding dysregulated cross-talk between these systems.

Schizophrenia · Aug 26, 2020Peer-reviewedNeuroscience

Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

Aidan J. McGlinchey, Tim Sinioja, Santosh Lamichhane, Partho Sen, Johanna Bodin, Heli Siljander, Alex M. Dickens, Dawei Geng, Cecilia Carlsson, Daniel Duberg, Jorma Ilonen, Suvi Mirjami Virtanen, Hubert A. A. M. Dirven, Hanne Friis Berntsen, Karin Elisabeth Zimmer, , Tuulia Hyötyläinen

This study examines how prenatal exposure to PFAS affects neonatal serum phospholipids and increases the risk of type 1 diabetes in offspring.

Environment International · Jul 4, 2020Peer-reviewedMolecular Biology

Metabolic Alterations in Human Peripheral Blood Mononuclear Cells Associate with Progression to Islet Autoimmunity and Type 1 Diabetes

Partho Sen, Alex M. Dickens, María Asunción López-Bascón, Tuomas Lindeman, Esko Kemppainen, Santosh Lamichhane, Tuukka Rönkkö, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Heikki Hyöty, Tuulia Hyötyläinen, Mikael Knip, Matej Orešič

The paper identifies metabolic patterns in PBMCs associated with progression to islet autoimmunity and T1D using longitudinal metabolomics and metabolic modeling.

bioRxiv · Jun 7, 2019 · PreprintMolecular Biology

Persistent alterations in plasma lipid profiles prior to introduction of gluten in the diet associate with progression to celiac disease

Partho Sen, Cecilia Carlsson, Suvi Mirjami Virtanen, Satu Simell, Heikki Hyöty, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Tuulia Hyötyläinen, Mikael Knip, Matej Orešič

The paper identifies lipid profile changes in children before gluten introduction that associate with progression to celiac disease.

Clinical and Translational Gastroenterology · May 10, 2019Peer-reviewedSystems Biology