Author

Christine McDonald

Cleveland ClinicORCID 0000-0002-6745-9487Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Erin E. JohnsoniD· 2 shared Ajay H. ZalavadiaiD· 1 shared András K. PontiiD· 1 shared Andrei I. IvanoviD· 1 shared Arif O. Khan· 1 shared Armando Marino-Melendez· 1 shared Atif ZafariD· 1 shared Christine M. O’ConnoriD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

Erin E. JohnsonORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Epithelial NCAPD3 expression protects against stress-induced intestinal injury in mice

Isabel Johnston, Erin E. Johnson, Arif O. Khan, Michelle S. Longworth, Christine McDonald

This study shows that NCAPD3 in intestinal epithelial cells protects against stress-induced injury in mice by maintaining barrier function and antimicrobial defense.

bioRxiv · Apr 27, 2026 · PreprintCell Biology

MYOSIN IIA MOTOR REGULATES ATTACHING-EFFACING BACTERIA INTERACTIONS WITH INTESTINAL EPITHELIUM

Nayden G. Naydenov, Atif Zafar, Susana Lechuga, Ajay H. Zalavadia, Armando Marino-Melendez, John A. Hammer, Velia M. Fowler, Christine McDonald, Kenneth G. Campellone, Andrei I. Ivanov

This study shows that NM IIA limits A/E bacterial colonization by inhibiting actin pedestal formation, while NM IIC does not play a similar role.

Gut Microbes · Feb 28, 2026Peer-reviewedCell Biology

N-phosphonacetyl-L-aspartate enhances type I interferon anti-viral responses through activation of non-canonical NOD2 signaling

András K. Ponti, Megan T. Zangara, Christine M. O’Connor, Erin E. Johnson, Christine McDonald

This study shows that PALA enhances antiviral responses by activating non-canonical NOD2 signaling, improving type I interferon production and ISG expression.

bioRxiv · Feb 8, 2022 · PreprintMolecular Biology