Andrew J. Stark

Lipopolysaccharide and Wzi retain capsular polysaccharide at the Klebsiella pneumoniae cell surface and promote bloodstream infection fitness

This study identifies LPS and Wzi as factors retaining CPS on K. pneumoniae and shows their importance for bloodstream survival.

Sugar Import Suppresses Klebsiella pneumoniae Mucoidy in cAMP-CRP-dependent Manner

This study shows that sugar import, not catabolism, suppresses mucoidy in hypervirulent K. pneumoniae via cAMP-CRP signaling, reducing rmpADC promoter activity and rmpD expression.

Connections between Klebsiella pneumoniae Bloodstream Dynamics and Serotype-Independent Capsule Properties

This study compares the pathogenic potential of classical and hypervirulent K. pneumoniae strains producing the K2 capsule, revealing differences in tissue tropism and mucoidy despite similar capsule production.

Arginine Regulates the Mucoid Phenotype of Hypervirulent Klebsiella pneumoniae

This study identifies arginine as a key regulator of mucoidy in hypervirulent Klebsiella pneumoniae, showing it activates the rmpADC promoter and modulates capsular polysaccharide chain length, impacting immune evasion and in vivo fitness.