Author

Kanishka Parashar

University of LausanneORCID 0000-0002-3211-6767Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Dorian V. ZiegleriD· 2 shared Lluis Fajas AiD· 2 shared Arianna RaveraiD· 1 shared B. Drake· 1 shared Carlos Henrique Venturi RonchiiD· 1 shared Catherine Roger· 1 shared Cathrin BriskeniD· 1 shared Christophe DessimoziD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Dorian V. ZieglerORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 6, 2025

CDK4 Restricts Triple-Negative Breast Cancer Cell Migration via Phosphorylation-Driven Activation of Myo9b RhoGAP Function

Kanishka Parashar, Laia Simó‐Riudalbas, Arianna Ravera…·Lluis Fajas A

This study shows CDK4 inhibits TNBC cell migration by phosphorylating Myo9b, which suppresses RhoA signaling, and suggests targeting Myo9b-RhoA could improve CDK4/6 inhibitor therapy.

1 citation

humanproteomics

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Cancer BiologyNature CommunicationsPeer-reviewedJan 9, 2025

CDK4 inactivation balances resistance to apoptosis with heightened metabolic sensitivity in triple negative breast cancer cells

Dorian V. Ziegler, Kanishka Parashar, Lucía C. Leal-Esteban…·Lluís Fajas

This study shows CDK4 inhibition in TNBC cells reduces apoptosis sensitivity and disrupts mitochondrial calcium signaling through MERCs, contributing to resistance to CDK4/6 inhibitors.

14 citations

humanproteomics

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