B. Drake

Deep-learning-assisted SICM for enhanced real-time imaging of nanoscale biological dynamics

This paper introduces a deep-learning-assisted framework to enhance real-time SICM imaging by reducing scan time while maintaining image quality and structural integrity.

CDK4 Restricts Triple-Negative Breast Cancer Cell Migration via Phosphorylation-Driven Activation of Myo9b RhoGAP Function

This study shows CDK4 inhibits TNBC cell migration by phosphorylating Myo9b, which suppresses RhoA signaling, and suggests targeting Myo9b-RhoA could improve CDK4/6 inhibitor therapy.

The human-restricted oncoprotein POU5F1B enhances cell invasiveness through plasma membrane remodeling

This study identifies POU5F1B as a human-specific oncoprotein that enhances cell invasiveness via plasma membrane remodeling through ubiquitination and S-acylation.

Spatially Multiplexed Single-molecule Translocations through a Nanopore at Controlled Speeds

This paper introduces a method to control single-molecule translocations through a nanopore with spatial and temporal precision, achieving high-resolution DNA analysis.

Time-resolved scanning ion conductance microscopy for three-dimensional tracking of nanoscale cell surface dynamics

This paper introduces a time-resolved scanning ion conductance microscope (SICM) for high-speed, long-term nanoscale imaging of live cell surface dynamics with sub-5nm axial resolution.

Correlative 3D microscopy of single cells using super-resolution and scanning ion-conductance microscopy

The paper combines scanning ion-conductance microscopy (SICM) with super-resolution optical fluctuation imaging (SOFI) to create correlative 3D cellular maps and visualize actin dynamics in live cells with subdiffractional resolution.