Lluis Fajas A

Inhibition of p107 alleviates liver steatosis by reducing de novo fatty acid synthesis.

This study shows that inhibiting p107 reduces liver steatosis by lowering de novo fatty acid synthesis and enhancing mitochondrial function in both mouse models and human hepatocytes.

CDK4 Restricts Triple-Negative Breast Cancer Cell Migration via Phosphorylation-Driven Activation of Myo9b RhoGAP Function

This study shows CDK4 inhibits TNBC cell migration by phosphorylating Myo9b, which suppresses RhoA signaling, and suggests targeting Myo9b-RhoA could improve CDK4/6 inhibitor therapy.

CDK4 inactivation balances resistance to apoptosis with heightened metabolic sensitivity in triple negative breast cancer cells

This study shows CDK4 inhibition in TNBC cells reduces apoptosis sensitivity and disrupts mitochondrial calcium signaling through MERCs, contributing to resistance to CDK4/6 inhibitors.

PamgeneAnalyzeR open and reproducible pipeline for kinase profiling

The paper introduces an R package for automated and reproducible analysis of kinase activity data from PamChip(R) arrays.