Hypothalamic estrogen receptor alpha mediates key side effects of tamoxifen therapy in mice
Zhi Zhang, Jae Whan Park, In Sook Ahn, Graciel Diamante, Nilla Sivakumar, Douglas V. Arneson, Xia Yang, J. Edward van Veen, Stephanie M. Correa
This study identifies hypothalamic estrogen receptor alpha as a mediator of tamoxifen-induced side effects in mice through single-cell RNA sequencing and genetic knockout experiments.
eLife · Mar 1, 2021Peer-reviewedNeuroscience