Douglas V. Arneson

The paper develops HIV-seq to capture HIV transcripts for scRNA-seq, revealing distinct transcriptional features of HIV-transcribing cells in viremic and ART-suppressed HIV patients.

The paper identifies distinct subtypes of cardiac-innervating sympathetic neurons using viral tracing and single-cell RNA sequencing, revealing their unique physiological roles in stress responses.

This study shows T4 treatment alters cell-type specific genes, pathways, and networks in hippocampus and frontal cortex after mTBI, reversing mTBI-affected genes and pathways.

JSTA improves spatial transcriptomics accuracy by jointly segmenting cells and annotating their types, revealing detailed spatial gene expression patterns in mouse hippocampus.

PharmOmics predicts drug repurposing by analyzing species- and tissue-specific drug signatures from genomic data and validates predictions in mice.

This study identifies hypothalamic estrogen receptor alpha as a mediator of tamoxifen-induced side effects in mice through single-cell RNA sequencing and genetic knockout experiments.

The paper identifies six distinct neuron clusters in the VMH using single-cell RNA sequencing and shows sex-specific differences in gene expression and function related to energy expenditure.

This study uses single-cell sequencing to identify hippocampal cell types and genes vulnerable to concussive TBI, revealing pathogenic mechanisms and therapeutic targets.