This study determines the cryo-EM structure of TASK-1 at low pH and shows how protonation of an extracellular histidine leads to channel closure, with mutations affecting proton sensitivity.

Structure · Jun 2, 2026Peer-reviewedBiophysics

The K18-hACE2 mouse model of SARS-CoV-2 infection to illustrate the role and response of the vasculature in neurotropic viral infection

Simon De Neck, Rebekah Penrice-Randal, Leandro Xavier Neves, Frauke Seehusen, Parul Sharma, Barbara Helminger, Adam Kirby, Daniele Mega, Maximilian Erdmann, Martina Zanella, Michelle E. Reid, Edward Emmott, Giuseppe Balistreri, Alaa Othman, Udo Hetzel, , Anja Kipar

This study uses a K18-hACE2 mouse model to show SARS-CoV-2 infects neurons in the brain without damaging blood vessels, leading to limited neuroinflammation.

bioRxiv · Feb 7, 2025 · PreprintPathology

Single cell profiling of the VMH reveals a sexually dimorphic regulatory node of energy expenditure

J. Edward van Veen, Laura G. Kammel, Patricia Bunda, Michaël Shum, Michelle Reid, Megan G. Massa, Douglas V. Arneson, Jae W. Park, Zhi Zhang, Anitta Joseph, Haley Hrncir, Marc Liesa, Arthur P. Arnold, Xia Yang, Stephanie M. Correa

The paper identifies six distinct neuron clusters in the VMH using single-cell RNA sequencing and shows sex-specific differences in gene expression and function related to energy expenditure.

Nature Metabolism · Apr 13, 2020Peer-reviewedNeuroscience