Maria B. Grant

Epigenome Alterations and 3D Chromatin Architecture Remodeling in Inflammatory Macrophage Activation under Diabetic Conditions

This study investigates how diabetic conditions alter the 3D chromatin architecture and epigenome of macrophages, revealing disease-associated rewiring of the 3D epigenome and potential therapeutic targets.

Retinoid X Receptor as a Therapeutic Target to Treat Neurological Disorders Associated with alpha-Synucleinopathy

This study shows that activating RXR reduces alpha-synuclein pathology and neuroinflammation in a mouse model of Parkinson's disease.

Glucose-Sensing ChREBP Protein in the Pathogenesis of Diabetic Retinopathy

This study investigates the role of ChREBP in diabetic retinopathy, finding its overexpression leads to metabolic reprogramming and retinal dysfunction in mice.

Retinoid X Receptor activation prevents diabetic retinopathy in murine models.

This study shows that RXR activation with UAB126 reduces hyperglycemia and improves retinal function in diabetic mice.

Depleting Hypothalamic Somatostatinergic Neurons Recapitulates Diabetic Phenotypes in Brain, Bone Marrow, Adipose, and Retina

This study shows that reducing hypothalamic somatostatinergic neurons in mice leads to diabetes-like symptoms in multiple tissues without hyperglycemia.