Anna Elizabeth Thalacker‐Mercer

Integrative Multi-omics Analysis of the Human Skeletal Muscle Response to Endurance or Resistance Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)

In 174 sedentary adults, resistance exercise changed more muscle molecular features than endurance exercise across omes and time points; network analysis nominates MEF2A and NFIC as regulatory hubs.

Distinct Myogenic Stages Recapitulate Transcriptomic Networks of Skeletal Muscle in COPD Cachexia

The paper identifies transcriptomic signatures of COPD and COPD-cachexia in skeletal muscle and shows they are preserved across differentiation stages in human muscle-derived cultures.

Vitamin B12 Improves Skeletal Muscle Mitochondrial Biology in Aged Mice

This study shows that vitamin B12 supplementation improves mitochondrial biology in aged mice by increasing mitochondrial content and reducing oxidative stress.

Vitamin B12 supports skeletal muscle oxidative phosphorylation capacity in male mice

This study shows that vitamin B12 deficiency impairs mitochondrial DNA integrity and oxidative phosphorylation in skeletal muscle, while B12 supplementation improves mitochondrial function in aged mice.

DOCK7 regulates WNT signaling and NMJ clustering in normal and DMD muscle

This study investigates the role of DOCK7 in skeletal muscle and motor neurons, showing its regulation of WNT signaling and AChR clustering in both normal and DMD muscle.

Glutamine deficiency enhances nuclear localization of TCA cycle enzymes and epigenetic modifications, impairing myogenesis

This study shows that glutamine deficiency reduces MPC proliferation by altering TCA cycle enzyme localization and epigenetic modifications, impairing myogenesis.

Small molecule oxybutynin rescues proliferative capacity of complex III-defective MPCs

This study shows that oxybutynin rescues proliferative capacity and metabolic function in Complex III-defective mitochondrial progenitor cells.

Suppressing PDGFRβ Signaling Enhances Myocyte Fusion to Promote Skeletal Muscle Regeneration

This study identifies PDGFRβ signaling as a regulator of myocyte fusion and muscle regeneration, showing that its suppression enhances muscle repair and myofiber size.

The myokine FGF21 associates with enhanced survival in ALS and mitigates stress-induced cytotoxicity

This study identifies FGF21 as a biomarker in ALS associated with slower disease progression and protective effects against stress-induced cytotoxicity.