Luisa Marie Schmidt

Gut Microbiota Fuel Aging Induced by Mitochondrial Dysfunction

This study shows mitochondrial dysfunction accelerates aging by disrupting gut microbiota structure and inducing immune dysregulation and inflammation through metabolic reprogramming.

Pulsed-SILAC in single mouse embryos reveals early embryonic protein synthesis dynamics and phosphosite regulation

The paper uses pulsed-SILAC in single mouse embryos to study protein synthesis dynamics and phosphosite regulation during early embryogenesis, revealing active maternal proteome synthesis and post-translational regulation.

Mapping the human sperm proteome across compartments, donors and individual cells

This study maps the human sperm proteome across compartments, donors, and individual cells, revealing conserved and variable proteins and linking mitochondrial dysfunction to male infertility.

miR-378a Controls Cardiomyocyte Metabolism and Angiogenic Signaling

This study investigates miR-378a's role in cardiomyocyte metabolism, mitochondrial function, and angiogenic signaling, showing its impact on cardiac performance and limited therapeutic benefit from overexpression.

Benchmarking enrichment and depletion methods for quantitative plasma proteomics in different plasma types and the correlation to clinical routine assays.

This study benchmarks enrichment and depletion methods for plasma proteomics across different plasma types and evaluates their correlation with clinical assays.

Single recipient cell tracking of tellurium-labeled extracellular vesicle proteomes (TeLEV) identifies EV-driven immunomodulation

The paper introduces TeLEV, a method to track EV proteomes in immune cells, revealing EV-driven immunomodulation through STAT5-dependent mechanisms.