RpS12-mediated induction of the Xrp1short isoform links ribosomal protein mutations to cell competition
Eleni N. Tsakiri, Myrto Potiri, Kyriaki Kontogiannidi, Katerina Douka, Kiriaki Kanakousaki, Nikoleta Vavouraki, Maria Loizou, Panagiotis Moulos, Efthimios M. C. Skoulakis, Martina Samiotaki, Panagiota Kafasla, Marianthi Kiparaki
The paper shows that RpS12 induces the Xrp1short isoform in Rp+/- cells, which is necessary and sufficient for their elimination, challenging existing models of ribosomal protein-linked fitness surveillance.
Cell Reports · May 22, 2026Peer-reviewedDevelopmental Biology