Panagiotis Moulos

Hepatitis B virus protein X promotes hepatocyte plasticity and survival in a differentiated human liver organoid system

This paper shows HBx promotes hepatocyte survival and reduces differentiation in human liver organoids, potentially contributing to liver cancer.

RpS12-mediated induction of the Xrp1short isoform links ribosomal protein mutations to cell competition

The paper shows that RpS12 induces the Xrp1short isoform in Rp+/- cells, which is necessary and sufficient for their elimination, challenging existing models of ribosomal protein-linked fitness surveillance.

Integrative analysis of patient-derived tumoroids and ex vivo organoid modeling of ARID1A loss in bladder cancer reveals therapeutic molecular targets

The paper identifies CHEK1 and BIRC5 as therapeutic targets in ARID1A-deficient bladder cancer using patient-derived tumoroids and public datasets.

Catchet-MS identifies IKZF1-targeting Thalidomide analogues as novel HIV-1 latency reversal agents

Catchet-MS identifies thalidomide analogues targeting IKZF1 as novel HIV-1 latency reversal agents by reversing latency in CD4+ T-cells.

The transcription factor Xrp1 orchestrates both reduced translation and cell competition upon defective ribosome assembly or function

This study identifies Xrp1 as a master regulator that triggers cell competition and translation deficits in response to ribosomal stress.

A two-color haploid genetic screen identifies novel host factors involved in HIV latency

This study identifies 10 novel host factors involved in HIV latency using a haploid genetic screen and validates their roles through functional assays and drug testing.