Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control
Daniel B. Grabarczyk, Julian F. Ehrmann, Paul V. Murphy, Woo Seok Yang, R Kurzbauer, Lillie Bell, Luiza Deszcz, Jana Neuhold, Alexander Schleiffer, Alexandra Shulkina, Juyeon Lee, Jin Seok Shin, Anton Meinhart, Gijs A. Versteeg, Eszter Zavodszky, , Tim Clausen
The paper presents the cryo-EM structure of the UBR4 complex, revealing its architecture and mechanism for substrate binding and ubiquitin chain extension in protein quality control.
Science · Aug 28, 2025Peer-reviewedBiochemistry