Author

Kent A. Arian

The University of Texas MD Anderson Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Bingrui LiiD· 3 shared Raghu KalluriiD· 3 shared Aaron A. Bickert· 2 shared Amari M. SockwelliD· 2 shared Anirban MaitraiD· 2 shared Hikaru SugimotoiD· 2 shared Krishnan K. MahadevaniD· 2 shared Michelle L. KirtleyiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Bingrui LiORCID

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Author profile →

3 papers

Recent·Most cited

TGF-β2-induced Snail-mediated EndMT signaling relies on both Smad-dependent and independent pathways

Valerie S. LeBleu, Bingrui Li, Anaïs M Comptdaer, Michelle L. Kirtley, Kent A. Arian, Xunian Zhou, Raghu Kalluri

The paper reproduces and validates a previously reported model of TGF-β2-induced EndMT through Smad-dependent and independent pathways across multiple studies and laboratories.

bioRxiv · Aug 20, 2026 · PreprintCell Biology

Distinct small molecule inhibitors of Kras specifically prime CTLA4 blockade therapy to transcriptionally reprogram Tregs and overcome resistance to suppress pancreas cancer

Krishnan K. Mahadevan, Ana S. Maldonado, Bingrui Li, Aaron A. Bickert, Adrian Perdyan, Shreyasee V. Kumbhar, Sujan Piya, Amari M. Sockwell, Sami J. Morse, Kent A. Arian, Hikaru Sugimoto, Shabnam Shalapour, David S. Hong, Timothy Paul Heffernan, Anirban Maitra, Raghu Kalluri

This study identifies small molecule Kras inhibitors that synergize with anti-CTLA4 therapy to reprogram Tregs and enhance immunotherapy efficacy in PDAC.

bioRxiv · Feb 28, 2025 · PreprintCancer Biology

CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in pancreatic ductal adenocarcinoma

Kathleen M. McAndrews, Krishnan K. Mahadevan, Bingrui Li, Amari M. Sockwell, Sami J. Morse, Patience J. Kelly, Sarah I. Patel, Michelle L. Kirtley, Barbara A. Moreno Diaz, Hengyu Lyu, David H. Peng, Xunian Zhou, Hikaru Sugimoto, Aaron A. Bickert, Lakshmi Kavitha Sthanam, , Raghu Kalluri

This study investigates how CDK8 remodels the tumor microenvironment to resist KRASG12D inhibition in PDAC, showing that targeting CDK8 can overcome resistance and improve survival.

bioRxiv · Jan 29, 2025 · PreprintCancer Biology