Author

Howard B. Broughton

Eli Lilly (Spain)ORCID 0000-0002-3293-3775Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron D. Showalter· 1 shared Alfonso EspadaiD· 1 shared An-Ping Yu· 1 shared Andreas BenderiD· 1 shared Anika LiuiD· 1 shared David Andrew CollieriD· 1 shared David B. WainscottiD· 1 shared Eamonn ReadingiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperBiochemistry

Aaron D. Showalter

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Structural dynamics underlying agonist activation of a GLP-1R-Gs precoupled complex

Jakub Sýs, Joseph D Ho, Aaron D. Showalter, An-Ping Yu, David B. Wainscott, Veronica Laos, Howard B. Broughton, Kyle W. Sloop, Alfonso Espada, Eamonn Reading

This study uses hydrogen-deuterium exchange mass spectrometry to analyze how non-peptide agonists and endogenous ligands modulate structural dynamics in a pre-coupled GLP-1R-Gs complex, revealing patterns linked to receptor activation.

bioRxiv · Aug 4, 2026 · PreprintBiochemistry

MAVEN: Compound mechanism of action analysis and visualisation using transcriptomics and compound structure data in R/Shiny

Layla Hosseini-Gerami, Rosa D. Hernansaiz-Ballesteros, Anika Liu, Howard B. Broughton, David Andrew Collier, Andreas Bender

MAVEN is an R/Shiny app that predicts drug targets and visualizes compound mechanisms of action using transcriptomics and chemical structure data, enabling hypothesis generation for wet-lab scientists.

BMC Bioinformatics · Sep 15, 2023Peer-reviewedSystems Biology