Kyle W. Sloop

This study uses hydrogen-deuterium exchange mass spectrometry to analyze how non-peptide agonists and endogenous ligands modulate structural dynamics in a pre-coupled GLP-1R-Gs complex, revealing patterns linked to receptor activation.

This study investigates the human Glp1r A316T variant's effects on glucose metabolism and GLP-1RA responses using mouse models and structural analyses.

This study evaluates the impact of an N-terminal Halo-tag on GIPR function in mice, finding reduced cAMP responses and impaired glucose tolerance in tagged mice.