Sahana Kumar

This study shows that adding lung surfactant Poractant alfa to lipid nanoparticles improves their performance for pulmonary mRNA delivery, increasing transfection efficiency and particle concentration.

This study shows that MUC5B and MUC5AC regulate mucociliary transport in airway epithelium by altering mucus biophysical properties based on their relative abundance.

The paper introduces an inverse Transwell assay to study mucus barrier function against respiratory viruses and identifies MUC5AC's role in antiviral defense.

This study shows that myeloperoxidase impairs mucociliary transport in human airway epithelium by increasing airway surface liquid viscosity, similar to neutrophil elastase.

This study investigates how the extracellular matrix affects AAV gene therapy by comparing diffusion and transduction efficiency across different AAV serotypes and ECM models.

This study evaluates AAV6-mediated MUC5AC siRNA delivery to reduce mucin overexpression and improve mucociliary clearance in asthma models.

This paper develops rapid in situ forming PEG hydrogels for mucosal drug delivery that degrade naturally and adhere to mucus-coated tissues.

This paper describes a method to isolate airway mucins from pig trachea at a large scale for pulmonary disease research, showing higher mucin content and microviscosity compared to gastric mucins and human mucus.