Allison Boboltz

MUC5B and MUC5AC function in combination to regulate mucociliary transport on human airway epithelium

This study shows that MUC5B and MUC5AC regulate mucociliary transport in airway epithelium by altering mucus biophysical properties based on their relative abundance.

An Inverse Transwell Assay for Airway Mucus Barrier Function Reveals both Virus- and Mucin-Specific Impacts on Infection

The paper introduces an inverse Transwell assay to study mucus barrier function against respiratory viruses and identifies MUC5AC's role in antiviral defense.

Airway mucins function as endogenous inhibitors of neutrophil extracellular traps

This study shows that airway mucus inhibits neutrophil extracellular traps (NETs) in a sialic acid-dependent manner, and mucus dysfunction in disease can impair this regulation.

Gene regulatory networks define human airway epithelial cell types and their distinct responses to type I interferon

The paper characterizes gene regulatory networks in human airway epithelial cells and identifies cell type-specific responses to type I interferon.

Myeloperoxidase impairs mucociliary transport on human airway epithelium

This study shows that myeloperoxidase impairs mucociliary transport in human airway epithelium by increasing airway surface liquid viscosity, similar to neutrophil elastase.

Female sex hormones enhance gonococcal colonization at the endocervix by modifying cervical mucus

This study shows that female sex hormones enhance gonococcal colonization at the endocervix by altering mucus production and structure, increasing bacterial microcolony size and number.

Synthetic mucus biomaterials synergize with antibiofilm agents to combat Pseudomonas aeruginosa biofilms

This study shows synthetic mucus biomaterials reduce Pseudomonas aeruginosa biofilm thickness and viability when combined with DNase and/or -amylase.

Scalable Extraction of Airway Mucins from Porcine Trachea

This paper describes a method to isolate airway mucins from pig trachea at a large scale for pulmonary disease research, showing higher mucin content and microviscosity compared to gastric mucins and human mucus.