Author

Vijay Soni

Weill Cornell MedicineORCID 0000-0002-3395-7429Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:cell-cell communication· 1 Approach:contrastive learning· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Kyu Young RheeiD· 3 shared A. M. SalehiD· 1 shared A. Paul Alivisatos· 1 shared Artem SokoloviD· 1 shared Bree B. AldridgeiD· 1 shared Dale Michael AndoiD· 1 shared Dirk SchnappingeriD· 1 shared Eric J. RubiniD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

Kyu Young RheeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action

William C. Johnson, A. Paul Alivisatos, Trever C. Smith, Nhi Van, Vijay Soni, Joshua B. Wallach, Nicholas A. Clark, Timothy A. Fitzgerald, Joshua J. Whiteley, Shumin Tan, Artem Sokolov, Dale Michael Ando, Dirk Schnappinger, Kyu Young Rhee, Bree B. Aldridge

This study introduces DECIPHAER, a tool that identifies critical mechanisms of tuberculosis drug action by integrating multi-modal data, revealing that respiration inhibition is more impactful than cell wall effects.

Cell Systems · Jul 29, 2025Peer-reviewedMicrobiology

Sugar phosphate-mediated inhibition of peptidoglycan precursor synthesis

Megan Renee Keller, Vijay Soni, Megan Brown, Kelly M. Rosch, A. M. Saleh, Kyu Young Rhee, Tobias Dörr

This paper identifies GlmU as a critical enzyme inhibited by sugar phosphates in Vibrio cholerae, linking glucose metabolism to cell envelope integrity and antibiotic susceptibility.

mBio · Jul 28, 2025Peer-reviewedMicrobiology

RNA polymerase-mediated regulation of intrinsic antibiotic resistance and bacterial cell division

Vijay Soni, Junhao Zhu, Yesha S. Patel, John D. Helmann, Eric J. Rubin, Kyu Young Rhee

This study identifies a novel mechanism by which rifampin shortens TB treatment by inhibiting Mtb RNA polymerase, leading to cell division arrest and reduced antibiotic resistance.

bioRxiv · Jul 20, 2025 · PreprintMicrobiology