Author

Hélène O. B. Gautier

University of CambridgeORCID 0000-0002-3302-9470Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

Ahmad Allouche· 1 shared Alexander K. WinkeliD· 1 shared Alexandre PonomarenkoiD· 1 shared Andrea DimitracopoulosiD· 1 shared Aurélie Batut· 1 shared B. G. C. MaisonneuveiD· 1 shared Daniel HaarhoffiD· 1 shared Eva K. PillaiiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Ahmad Allouche

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Neurons as biosensors for discriminating neurological disorders in a brain-on-chip platform: Application to Alzheimer s Disease using patient CSF

Louise Miny, Jessica Rontard, Ahmad Allouche, Nicolas Violle, Louise Dubuisson, Aurélie Batut, Alexandre Ponomarenko, Rania Talbi, Hélène O. B. Gautier, B. G. C. Maisonneuve, Serge Roux, Florian Larramendy, Thibault Honegger, Isabelle Quadrio

The paper uses a brain-on-chip platform with human neurons to differentiate Alzheimer's disease and healthy CSF samples based on electrophysiological responses to Aβ peptides.

bioRxiv · Aug 23, 2024 · PreprintNeuroscience

Substrate stiffness regulates neuronal maturation via Piezo1-mediated TTR activity

Eva Kreysing, Hélène O. B. Gautier, Sudipta Mukherjee, Katrin A. Mooslehner, Leila Mureşan, Daniel Haarhoff, Xiaohui Zhao, Alexander K. Winkel, Tina Boric, Sebastián Vásquez-Sepúlveda, Niklas Gampl, Andrea Dimitracopoulos, Eva K. Pillai, Robert Humphrey, Ragnhildur Thóra Káradóttir, Kristian Franze

This study shows that substrate stiffness affects neuronal maturation by regulating Piezo1-mediated TTR activity, delaying synapse formation and electrical maturation.

bioRxiv · Jul 25, 2024 · PreprintDevelopmental Biology