Leila Mureşan

Early synaptic pathology is associated with small tau aggregates in Alzheimer's disease

The paper examines tau aggregates in Alzheimer's disease synaptosomes, finding that small tau aggregates are associated with early synaptic pathology.

3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain

This study uses 3D super-resolution microscopy to analyze PSD95 nanoarchitecture in the mouse brain, revealing diffuse supercomplexes outside synapses and distinct subtypes within synapses.

Live imaging human embryos reveals mitotic errors and lineage specification prior to implantation

This study uses live imaging to show mitotic errors and lineage plasticity in human embryos before implantation, revealing implications for aneuploidy mosaicism.

Substrate stiffness regulates neuronal maturation via Piezo1-mediated TTR activity

This study shows that substrate stiffness affects neuronal maturation by regulating Piezo1-mediated TTR activity, delaying synapse formation and electrical maturation.

Transcriptionally active chromatin loops contain both active and inactive histone modifications that exhibit exclusivity at the level of nucleosome clusters

The paper uses super-resolution microscopy to study histone modifications in Drosophila Y loops, revealing exclusivity of modifications at the chromatin cluster level and their association with transcriptional activity.

Changes in searching behaviour of CSL transcription complexes in Notch active conditions

The paper investigates changes in CSL transcription complex behavior under Notch active conditions using single molecule microscopy, finding increased binding and exploratory behavior.

BigNeuron: A resource to benchmark and predict best-performing algorithms for automated reconstruction of neuronal morphology

BigNeuron benchmarks automatic neuron reconstruction algorithms using gold standard annotations and image quality metrics, showing that consensus methods outperform individual algorithms.

The individual vulnerability to develop compulsive adjunctive behavior is associated with the recruitment of activity-regulated cytoskeleton-associated protein (Arc) within the Locus Coeruleus

The paper identifies a correlation between low Arc mRNA levels in specific locus coeruleus neurons and the development of compulsive polydipsic drinking in rats.

The anatomy of transcriptionally active chromatin loops in Drosophila primary spermatocytes using super-resolution microscopy

This study uses super-resolution microscopy to analyze the structure of transcriptionally active chromatin loops in Drosophila primary spermatocytes, revealing their organization into nucleosome clusters and RNA polymerase foci.

The zebrafish presomitic mesoderm elongates through compression-extension

This study shows that zebrafish presomitic mesoderm elongates through compression and cell density increase, not posterior growth, and tail somites form without PCP signaling.

MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling

The paper shows MAVS polymers induced by dsRNA are smaller than 80 nm and require the transmembrane domain for mitochondrial remodeling and interferon signaling.

4D imaging reveals stage dependent random and directed cell motion during somite morphogenesis

The paper uses live imaging to study cell movement during somite formation in chick embryos, revealing both random and directed motion in different regions.

Neuromesodermal Progenitors are a Conserved Source of Spinal Cord with Divergent Growth Dynamics

The paper traces neuromesodermal progenitors in zebrafish embryos to show they contribute to spinal cord and mesoderm with distinct growth dynamics across species.