Author

Sabine A. K. Fraschka

Radboud University NijmegenORCID 0000-0002-2401-3784Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Carlo Fiore ViscomiiD· 1 shared Dario BrunettiiD· 1 shared Dina Ivanyuk· 1 shared Dina VlachouiD· 1 shared Gabriele Di NapoliiD· 1 shared George K. ChristophidesiD· 1 shared Kathrin WitmeriD· 1 shared Maria Jose Perez J.iD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Carlo Fiore ViscomiORCID

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2 papers

Recent·Most cited

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids

Maria Jose Perez J., Dina Ivanyuk, Vasiliki Panagiotakopoulou, Gabriele Di Napoli, Stefanie Kalb, Dario Brunetti, Rawaa Al‐Shaana, Stephan A. Kaeser, Sabine A. K. Fraschka, Mathias Jucker, Massimo Zeviani, Carlo Fiore Viscomi, Michela Deleidi

This study shows that PITRM1 deficiency in human cerebral organoids leads to Alzheimer's-like pathology, including protein aggregates and tau pathology, while 2D cultures do not show these features.

Molecular Psychiatry · Jul 6, 2020Peer-reviewedNeuroscience

Epigenetic regulation underlying Plasmodium berghei gene expression during its developmental transition from host to vector

Kathrin Witmer, Sabine A. K. Fraschka, Dina Vlachou, Richárd Bártfai, George K. Christophides

The paper investigates epigenetic regulation in Plasmodium berghei during its developmental transition, identifying HP1 and H3K9ac roles in gene expression and uncovering DNA motifs associated with ookinete-specific genes.

Scientific Reports · Apr 14, 2020Peer-reviewedGenomics