Author

Mackenzie N. Kehmeier

University of OregonORCID 0000-0002-3328-8499Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Abigail E. CulleniD· 2 shared Ashley E. WalkeriD· 2 shared Nabil J. AlkayediD· 2 shared Thomas Leonhardt· 2 shared Alexandra FamianoiD· 1 shared Benjamin ZimmermaniD· 1 shared Carrie E. McCurdyiD· 1 shared Daniel J. TyrrelliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Abigail E. CullenORCID

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2 papers

Recent·Most cited

APOE4 genotype and old age interact to impact cerebrovascular function, brain volume, and neuroinflammation in mice

Mackenzie N. Kehmeier, Young Deanna Choi, Abigail E. Cullen, Benjamin Zimmerman, Thomas Leonhardt, Maddie Snyder, Tucker Cleveland, Naly Setthavongsack, Randy Woltjer, Martin M. Pike, Nabil J. Alkayed, Ashley E. Walker

This study investigates how APOE4 genotype and old age interact to affect cerebrovascular function, brain volume, and neuroinflammation in mice, finding that the interaction impacts these outcomes while age alone affects cognitive function and arterial stiffness.

bioRxiv · Jul 11, 2026 · PreprintNeuroscience

APOE4 genotype negates the benefits of 17β-estradiol on cerebrovascular endothelial and mitochondrial function

Mackenzie N. Kehmeier, Alexandra Famiano, Abigail E. Cullen, Thomas Leonhardt, Skylyn Ferguson, Madeleine Snyder, Carrie E. McCurdy, Daniel J. Tyrrell, Nabil J. Alkayed, Ashley E. Walker

This study shows that 17β-estradiol improves cerebrovascular endothelial and mitochondrial function in APOEε3 mice but not in APOEε4 mice.

bioRxiv · Jul 23, 2025 · PreprintPhysiology